The Candida Expert

Candida and Diabetes

Common symptoms associated with candida infections include hypoglycemia and insulin resistance. These often occur together in many people. Hypoglycemia is low blood sugar and insulin resistance is high blood sugar. Left alone long enough in the body, they can develop into diabetes. So what’s the connection with candida?

To discover this, we need to know more about how candida functions in the body. Candida has an amazing ability to adapt to the various environments found in the body’s many organs and tissues. When sugar is absent, it switches to burning fat as it’s main fuel source. So much for all of the candida diets that heavily restrict sugar. More about that in another post. Candida can thrive on sugar however and uses whatever is at hand, as well as creating conditions that serve it’s ability to continue to grow and spread.

The main mechanism by which candida causes tissue destruction in the human body is via a group of protease enzymes called Secteted Aspartyl Proteases (SAPs). Protease enzymes are responsible for breaking down protein and protein structures. SAPs are also considered to be candida’s main mechanism of virulence or pathogenicity – how it spreads in the body and causes damage.
Researchers at UCSD discovered that protease enzymes can lead to diabetes, hypertension, and immune system suppression (3 common symptoms of candida infections). They create diabetes by destroying the receptors on cells that insulin binds to. Insulin is a hormone produced by the pancreas gland. It works like a key in that it attaches to a receptor site on cells, which then opens gates in the cell wall that allow sugar to enter the cell and be used as a fuel. Without insulin or the receptors, sugar stays in the blood stream and continues to build up, leading to problems in regulating blood sugar.

Through SAPs, candida can destroy the protein-based receptors on the cell walls, leading to higher levels of sugar circulating in the body. These same SAP enzymes can destroy attachment sites on white blood cells that enable the ability of white blood cells to leave the blood stream and enter tissues where an infection is taking place. The mechanism of how they create hypertension is still not clear.


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Comments on: "Candida and Diabetes" (4)

  1. Dear Dr. McCombs

    Thank you very much for this interesting article.
    I would like to know how you handle this with your patients when they are insuline restistant and have candida. When doing the Candida diet no sugars are allowed, not even most of starches and carbs. But people with insuline restistance have then a lot of bad symptoms because they have not enough glucose in the whole body and especially in the brain. That can lead to symptoms like fatigue, mood swings, depression, low body energy etc.
    For a couple of weeks this is bearable. But normally people have to stuck on the diet for a couple of month.
    Is there anything that could be done for avoiding low glucose for such a long time (especially in the brain)?

    Thank you for your answer!

  2. Last winter I devoloped a severe candida infection. since then I have devoloped type 1 diabetes, celiac, hyperthyroidism and a autoimmune skin condition related to celiac. I read somewhere that gluten and candida share a protein sequence. Is it possible that my immune system is being tricked by candida to attack my body or getting confused by similar protein sequences?

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