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Antibiotics Cause Candida

This article from the Departments of Microbiology and Immunology and Medicine at Albert Einstein College of Medicine is one of the best articles that I’ve read in a while as it addresses the idea and concept of pathogenicity very well. At the same time, I consider it to be an indictment on the poor state of medicine as it is currently practiced. Conversely, it vindicates the centuries old approach to healing as practiced by holistic doctors around the world – http://www.biomedcentral.com/1741-7007/10/6

Pathogen vs. Non-pathogen –

“…this takes us to an ongoing debate that dates back to the late 19th century when the [Pasteur] germ theory of disease was established. …even then it was obvious that neat classifications were problematic, for it was known that a microbe could be attenuated in the laboratory, but virulence could be restored by passage in a host, suggesting that the same microbe could exist in pathogenic and non-pathogenic states.”

Pasteur’s famous confession on is deathbed that he was wrong about his germ theory was in reference to this as he finally realized that the interaction between the host and the microbe was the determining factor for infection, not the microbe itself. Pasteur’s theory was openly opposed by scientists at the time, as they better understood the host-microbe interaction, however Pasteur held a government position allowing him to craft “official” policy (similar to what’s happening at the FDA today). The pharmaceutical industry has found it to be more profitable to market Pasteur’s germ theory, instead of his later understanding and now current science’s opinion, that the host-microbe interaction is the most important consideration.

“…properties conferring pathogenicity depend as much on the host as they do on the microorganism…it was developments in the 20th century that clearly obliterated the hope of ever drawing a clear and unequivocal line of distinction between pathogens and non-pathogens. Beginning in the 1950s the introduction of broad spectrum antimicrobial agents, immunosuppressive therapies, newer types of surgery, including organ transplantation and joint replacement, implantable devices and indwelling catheters, each of which alters host-microbe interactions, turned out to create conditions in which the host became vulnerable to microbes that were previously considered non-pathogenic. As a result, it became apparent that many microbes previously considered non-pathogenic, or rarely pathogenic, such as Staphylococcus epidermis and Candida albicans, could cause serious disease.”

I would correct the 3rd line to “Beginning in the late 1940s” as that was when antibiotics were introduced and there was a significant jump in fungal Candida albicans cases. The early 1950s saw an even more significant jump in candida albicans cases, along with a strong push in research around candida infections and resulting conditions, as antibiotic use continued to escalate. Of those therapies listed above, it was antibiotic use that created the most significant change. Here we start to see why the medical profession isn’t readily willing to look at systemic fungal Candida as a result of antibiotic use. The widespread use of antibiotics creates an even greater problem by altering the host’s ability to resist infections that are created by their use. Antibiotics empower the pathogen and weaken the host. Some antibiotics have been implicated as a direct trigger for then conversion of the normal yeast form of Candida to it’s pathogenic fungal form. Most research shows that it alters the host terrain, creating the conditions necessary to cause the yeast-fungal conversion.

“Antibiotics make people more vulnerable to microbe-mediated damage because they alter the microbiota, or the normal microbial flora, and the balanced relationships between the microbes that reside in the mucosal niches in the body and the host structures that support these communities. Surgery can have the same effect by removing or altering normal mucosal and cutaneous barriers to infection. So the effects of antibiotics and surgery enhance the pathogenicity of microbes that do not ordinarily cause damage or disease in normal microbial communities, or intact mucosal and cutaneous surfaces, by making the host more susceptible to damage or invasion.”

Is there any more that needs to be said? Thank you Albert Einstein College! You do your namesake great credit. I would like to say more, however. Antibiotic use is not only associated with these immediate effects, but they can permanently alter the make-up of the intestinal flora, and are being implicated in more serious diseases and conditions such as life-threatening colitis, diabetes, cancers, obesity, and a host of as yet other unknown diseases – http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0060280

“many microbes that cause disease are already present in the individual and the individual is thus already ‘infected’. This is exemplified by microbes such as staphylococci and Candida spp., which are actually present in most individuals, but only cause disease in some. This also applies to many other microbes, including those to which an individual is immune, either through prior infection or through vaccination, as immune individuals are recognized as being resistant to the capacity of a microbe to cause disease.”

Health is a state of constant vigilance and maintenance. When you consider that most everyone already carries a heavy body burden of tens of thousands of chemicals and heavy metals from the environment, foods, and water from past exposures, and is constantly faced with even more, it becomes clearer how maintaining health has become an challenge.

“…when a host is immune, pathogenicity is not expressed. What is important to recognize is that pathogenicity and virulence are microbial properties that can only be expressed in a susceptible host.”

Health is a state of constant vigilance and maintenance. Worth repeating.

“…pathogenicity is an outcome of host-microbe interaction and is thus inextricably linked to characteristics of the host as well as those of the microbe. Rather than distinguishing commensals from pathogens/non-pathogens, the immune system of healthy hosts actually depends on these microbes. Commensals (also called the microbiota) are acquired by infection soon after birth, after which they establish residence in mucosal niches where they replicate, and there is increasing evidence that the microbiota play a crucial role in the development of the immune system and that the immune response to the bacteria in mucosal niches helps maintain barriers to invasion on surfaces exposed to potentially harmful microorganisms. The commensal bacteria themselves do no harm, provided that the immune system and mucosal barriers remain normal and intact. The immune system provides a large variety of tools – cells and molecules – that recognize, react to and control microbial growth and invasion, often in a manner that does not result in host damage or disease, and when this happens, there is no readout. In this instance, the immune system might be thought to have distinguished a pathogen from a non-pathogen, but in fact, it simply controls microbial growth and/or invasion in a manner that does not translate into microbial pathogenicity.”

The intestinal tract is an ecosystem composed of bacteria and other micro-organisms. As a whole, it doesn’t matter if some are pathogenic and some are commensal/friendly. They all exist in a harmonious state, as long as the host is healthy. Antibiotics disrupt this harmony.

“An interesting paradox occurs in the case of two bacteria that produce toxins generally regarded as factors increasing the virulence of the microbe: staphylococci that produce a so-called leukocidin, and pneumococci that produce a toxin called pneumolysin. Because these toxins also activate the innate immune response, bacteria that do not produce them can sometimes be more pathogenic than bacteria that do. Thus, when the immune response to a microbe is insufficient, microbial factors can cause damage, and when microbial factors fail to stimulate the immune system, the microbe can disseminate and cause disease.”

The standard medical approach is to see everything as bad and the body doesn’t know what its doing, regardless of what science continues to reveal. It’s not a black and white picture, it’s everything taken as a whole. These type of paradoxes in the human body are present everywhere. As I constantly point out to people when I lecture, we know about 1% of what goes on in the human body.

“At the other end of the spectrum, when the immune response to a microbe is too exuberant, it can be the immune response itself that is responsible for the pathology. When damage occurs in this setting, it is most commonly due to detrimental inflammation and can occur whether the microbe is controlled or contained or not.”

Crohn’s, IBS, IBD, and Colitis are good examples of this. Some authors have stated that most autoimmune diseases originate with imbalances in the intestinal tract.

“There is no difference between an opportunistic pathogen and any other kind of pathogen. Both are microbes and both have the potential to cause damage/disease in a host. The definition that is often used for opportunistic pathogens is that these microbes cause disease in people with impaired immunity but not in normal individuals. However, this definition is purely operational: the same microbe – consider Candida albicans and Staphylococcus epidermidis – can cause disease in one individual but live harmlessly in others, which means that the same microbe would be called an opportunist in one individual and a commensal in another. Indeed, the identification of certain microbes as a cause of disease in certain hosts can unmask or be a sentinel for an underlying immunodeficiency.”

Another way to look at this is, “if you have an infection, it’s diagnostic of a deficient or altered immune response.” One of the most consistent effects of antibiotic use is suppression of the immune system. It doesn’t make sense to suppress the immune system further, when it is already struggling. The reason that most doctors use it and most people continue to turn to its use is that it suppresses the normal immune response that causes the common symptoms of fevers, aches, and pains. It is the suppression of the normal inflammatory response that makes people “feel” better, but at the same time alters the natural healing process of the body. This process is necessary to promote ongoing immune function and improvement of health in the body. Pharmaceutical companies through advertising have raised a generation of doctors and consumers believing that we shouldn’t have to deal with that. We need to quit interfering with the body’s normal healing process by using drugs.

“…there are only microbes and hosts and the outcomes of their interactions, which include commensalism, colonization, latency and disease. Hence, attempts to classify microbes as pathogens, non-pathogens, opportunists, commensals and so forth are misguided because they attribute a property to the microbe that is instead a function of the host, the microbe, and their interaction.”

The entire approach of antibiotic use is severely questioned with the above statement. Antibiotics destroy the balance of the host leaving us susceptible to any number of pathogens, along with newly created antibiotic-resistant superbugs. Antibiotic resistance is now classified as the 3rd leading threat to human health by the World Health Organization (WHO). Antibiotics are connected to life-threatening colitis, diabetes, obesity, and cancers. Antibiotics are part of the problem.

“Pathogenicity and virulence are emergent properties, meaning that they cannot be predicted directly from the properties of the microorganism. The environment, an individual host or population of hosts and/or an individual microbe or population of microbes can change independently, or as a function of complex interactions, including those between environment and host, host and microbe, microbe and environment, and all three. Thus, microbial pathogenicity is intrinsically unpredictable. Host and microbial characteristics are subject to predictable and unpredictable changes prompted by known, unknown, and random environmental, immunological, and other factors. Thus, as it is an outcome of host-microbe interaction whereby each entity is subject to independent and dependent changes at any point in time, pathogenicity is an emergent property.”

This paragraph brings into question the use of vaccines as effective therapies, as well as all antimicrobial drugs. I think that it also points out the reversibility of conditions and diseases by improving host-microbe interactions, not destroying them.

“…however, neither the complexity nor the variability or randomness that occurs in nature occurs or can be recapitulated in models systems. Thus, while predictions on how given (known) variables might affect the potential for a (new) microbe to be pathogenic in a given (known) population might be possible, such predictions are only possible in the context of available knowledge and paradigms. This being the case, prediction of the emergence of new microbes with the potential for pathogenicity will always be subject to severe limitations.”

This paragraph, along with the preceding one, are important because it explains why infectious agents like the H5N1 Bird flu have never materialized into the epidemic that pharmaceutical companies would have us believe in order to get us to use their vaccines. In general, it implicates all vaccines. This paragraph also points out how limited current science is, even though we’re always being lead to believe that the “authorities” are knowledgeable beyond any doubt and we should do whatever they say or recommend. Obviously not. Just say, “No!”

Excerpts from:
Q&A: What is a pathogen? A question that begs the point
Liise-anne Pirofski and Arturo Casadevall
Departments of Microbiology and Immunology and Medicine (Division of Infectious Diseases) of the Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Ave, Bronx, NY 10461, USA
BMC Biology 2012, 10:6

 

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Candida Linked To Arthritis, Multiple Sclerosis, Psoriasis, and Other Autoimmune Conditions

In this recent study, Candida albicans was shown to cause inflammatory and autoimmune reactions that lead to arthritis, psoriasis and other skin rashes, multiple sclerosis, and many other conditions and diseases – http://candidaplan.com/blog/620/candida-linked-to-arthritis-multiple-sclerosis-psoriasis-and-other-autoimmune-conditions/

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Can You Eat Too Many Healthy Fruits and Veggies?

Is it possible to overeat healthy foods? I guess that would depend on the context. The point of the article below is that it is possible to consume too many calories and gain weight, regardless of whether the food is healthy or not. Contrary to this type of logic however, when doing Dr. McCombs Candida Plan – http://candidaplan.com/, we find that eating plenty actually helps to increase weight loss. This is due to the fact that detoxifying the body takes lots of energy and you need to fuel this process. Many people comment that they “haven’t eaten this much in years and they’re still losing weight,” which brings us back to context. Here’s the short article anyway – http://www.sciencedaily.com/releases/2012/07/120724144423.htm

It may make you scratch your head, but in fact it is possible to overeat healthy foods, according to Loyola University Health System registered dietitian Brooke Schantz.

“While fruits are nutritious, too much of even a healthy food can lead to weight gain,” Schantz said. “The key is to remember to control the portion sizes of the foods you consume.”

Schantz reported that overeating healthy foods is easy to do, but the same rules apply to healthy food as junk food. Weight fluctuates based on a basic concept — energy in versus energy out. If your total caloric intake is higher than the energy you burn off in a day, you will gain weight. If it is lower, you will lose weight.

“I have had many patients tell me that they don’t know why they are not losing weight,” Schantz said. “Then they report that they eat fruit all day long. They are almost always shocked when I advise them to watch the quantity of food they eat even if it is healthy.”

Schantz said that one exception applies. Nonstarchy vegetables are difficult to overeat unless they are accompanied by unnecessary calories from sauces, cheeses and butter. This is due to the high water and fiber content of these vegetables coupled with the stretching capacity of the stomach. The vegetables she suggested limiting are those that are high in starch, such as peas, corn and potatoes. Foods that are labeled as fat-free or low-fat are another area of concern.

“People tend to give themselves the freedom to overeat ‘healthy’ foods,” Schantz said. “While the label might say that a food or beverage is low-fat or fat-free, watch the quantity you consume and refrain from eating an excessive amount. Foods that carry these health claims may be high in sugar and calories.”

Context, context, context!

Q&A with Dr. McCombs from New Year’s 2011

Antibiotics and Candida

I often get asked about antibiotics and systemic candida. Antibiotics are definitely the best way to create systemic fungal infections and lifelong intestinal flora imbalances in the body, as well as an unlimited number of other problems. Although the medical profession doesn’t even acknowledge this, scientists and researchers state this obvious fact over and over again.

 

Antibiotics kill good and bad bacteria. Killing these bacteria causes a massive hemorrhaging of the internal components of all bacteria. This is particularly problematic because our bodies respond to these internal components by producing acute and eventually chronic long-term inflammation that can affect all tissues and cells throughout the body. This massive inflammatory cascade can breakdown tissues and interfere with cellular function. One of these internal substances, Lipopolysaccaharide (LPS) is common in gram-negative bacteria and is a substance that most researchers use in laboratory testing due to the overwhelming reliable strong immune response that it causes.

 

Some of these intracellular bacterial components, like Peptidoglycans (PGN) also act directly on the cellular membrane of the yeast Candida Albicans causing it to transform into its pathogenic fungal form. This is in addition to antibiotics eliminating millions of beneficial bacteria that help to keep the Candida Albicans yeast within ratios that benefit the overall health of the intestinal tract and therefore the rest of the body.

 

Antibiotics can also suppress the immune system response. This primarily affects the macrophages which go around cleaning up pathogenic organisms that would otherwise harm us. By suppressing macrophages, antibiotics can reduce the pro-inflammatory cascade which macrophages play a big role in initiating. While this may seem beneficial, it actually aids in the spread of the pathogenic fungal form of C. Albicans. First, with antibiotic-induced suppression of the immune system, the fungal candida now can spread more rapidly without macrophages to inhibit it. Secondly, by suppressing the macrophages and the inflammatory response, the liver does not release positive acute-phase proteins which are necessary for preventing the spread of pathogenic organisms throughout the body. Three of these acute-phase proteins (Ferritin, Ceruloplasmin, & Haptoglobin) function by binding iron and making it unavailable to pathogenic fungal candida. Without these 3 proteins, fungal candida can now attach itself to our blood cells and feed on an unlimited source of iron in the form of hemoglobin to help it spread throughout the body. This also goes for other pathogenic microbes that will be spreading as a result of the effect of antibiotics in the body. 

 

By killing off the beneficial bacteria that inhabit and help to regulate the normal healthy intestinal flora, we lose the beneficial enzymes and acids that these organisms produce. This causes the pH of the intestinal tract to become more alkaline. An alkaline intestinal pH also promotes the conversion of C. Albicans into its pathogenic fungal form. When the intestinal pH is acidic, candida remains in its normal yeast form. 

 

The above examples are just some of the ways that antibiotics promote and maintain the ongoing growth and spread of fungal candida throughout the body.

 

Killing off the beneficial bacteria also leads to decreased absorption of nutrients that our cells and tissues need to function in a healthy state. Certain strains of acidophilus help to synthesize B vitamins. A deficiency of these alone would create innumerable problems within the body.

 

There are an estimated 100 trillion micro-organisms within the intestinal tract. For many years, researchers were able to identify some 300-500 species of micro-organisms that were responsible for making up the 100 trillion cells. Recent advances in the use of technology have now identified close to 6,000 species in the large intestine alone. Most of what these organisms do and how they interact is unknown. As long as there is a sufficient amount of beneficial bacteria to keep everything in balance, then we have a better chance at staying healthy. Research now tells us that some these species are permanently eliminated from the body by the use of antibiotics – http://www.sciencedaily.com/releases/2008/11/081118121941.htm.

 

Apart from the use of antibiotics being responsible for thousands of deaths and over 144,000 visits to emergency rooms each year in the U.S. alone, the incidence of antibiotic resistance continues to escalate worldwide to the point that we are rapidly approaching a new era where antibiotics won’t be useful for most people – http://www.sciencedaily.com/releases/2009/01/090128183925.htm.

As this continues to happen, we will see an increase in the use of natural methods that help restore balance without creating additional problems. This is the goal of the McCombs Plan for Health, Vitality, and Transformation – http://mccombsplan.com/.

A “S.A.D.” Lifestyle

As our country deals with the effects of past deregulation and the current financial crisis, I am struck by how America has also become deregulated in the area of its dietary choices and the resultant health crisis that is developing as a result. Sound dietary practices have been dismantled and replaced by eating whenever, whatever, and however it suits us in the moment. Common sense management of our food choices has been neglected in favor of fad diet fixes and Flintstone vitamins.

The wisdom of the body as a temple that needs to be cherished and cared for has been replaced by the philosophy of the body as an amusement park and I’ve got a season pass.

It’s no mistake that the acronym for the Standard American Diet is S.A.D. When America exports the dietary principles of S.A.D. to another country, a decline in the health of its people quickly follows. It also holds true for foreigners who immigrate here, as they quickly find out that their health declines and their weight increases when eating as the natives do. In all fairness, America should have signs at its entry borders that warn of the risks that go with adopting our S.A.D. lifestyle.

Using the government’s Body Mass Index (BMI) standard, a calculation based on height and weight, over 66% of Americans are overweight and 34% are obese. If current trends continue, by 2015, it’s estimated that 75% of American adults will be overweight or obese. By 2030, that estimate increases to more than 86 percent of adults, and by 2048, well let’s just say that finding a normal weight person will be like finding a needle in a haystack. The BMI standard isn’t without just criticism, as other body measurements are not considered. When considering the overall trend, however, it’s obvious that Americans are getting fatter and the associated illnesses and healthcare costs that accompany this trend are also on the rise.

Being overweight increases our risk of diabetes, high blood pressure, heart disease, stroke, cancer, liver and gall bladder disease, osteoarthritis, infertility, and various other related diseases and conditions. All of these are signs of lifestyle mismanagement, not medication deficiencies.

I imagine that a pharmaceutical company’s Board of Directors looks upon America’s sedentary lifestyle and standard diet much in the same way that a cannibal looks upon a newly caught fat missionary prior to feasting. Our gains become their gains.

The pharmaceutical industry continues to propagate the philosophy of there’s nothing wrong with us. It’s not our fault. It’s just genetics, hormones, and other uncontrollable dysfunctions in our bodies that they will soon have a drug for. So, don’t worry, keep eating. For heaven’s sake, there’s no need to deprive your self of anything. Eat! You’ve earned it. Eat! You deserve it. Eat! It’s the holidays. Eat, eat, eat!

President-Elect Barack Obama keeps reminding us that we need to prepare ourselves for making sacrifices in order to correct the excesses of the past. This applies as much to our diet and lifestyle choices as much as it does to the economy. If sacrifices are to be made, then we can choose to sacrifice stupidity for wisdom. We can live up to our potential and leave behind the excuses and reasons for not taking care of ourselves.

Over half of Americans lead a sedentary lifestyle. The current government recommendation calls for 30 minutes of exercise 5 days a week. I have always thought that the government usually gets it half-right. Exercising 60 minutes 5 days a week is probably even better. Start where you are and go from there. Leave the “have to do it/be it/have it now” attitude behind. Evolve your desires to allow for gradual progress to have its impact.

In his book “What May Be” Piero Ferrucci states, “You must not follow your feelings. Your feelings must follow you.” We must begin to exhibit an emotional intelligence that directs our food choices. We must eat with a conscious awareness of how we wish to transform our bodies, for our bodies are transforming from moment-to-moment whether we like it or not. How it transforms can be up to us.

So as Thanksgiving approaches, I believe that it’s time to be thankful for the abundance and opportunities that we have as Americans. It’s time to invest in ourselves and our future. We can create something remarkable with our lives and share our life stories with others. We can be a nation of everyday heroes, ordinary people living extra-ordinary lives.

As an old adage states, “If not now, when? If not me, who?”

Dr. Jeffrey S. McCombs is a 3rd generation Doctor of Chiropractic, author of the book “LifeForce,” and developer of the McCombs Plan. His 25 years of ongoing research and practice emphasizes addressing the nutritional, biochemical, structural, emotional, and environmental aspects of acute and chronic health conditions in his patients.

He can be reached at www.mccombsplan.com or 888-236-7780.

Healthcare Abducted

Mainstream healthcare in America has been abducted by the pharmaceutical and insurance companies. As profits have moved to the center stage, patient care has become secondary.

 

We need to make healthcare more affordable for Americans once more. We can start by creating a law that drugs in the U.S. be sold at world market prices. This would eliminate the excessive profits that allow Pharmaceutical Giants to support the biggest lobby and drug marketing programs the world has seen. Drug sales in the U. S. accounts for almost half of the $643 billion world pharmaceutical market.

 

Year after year drug companies enjoy higher profits than any other industry in the United States. In 2002, the top 10 drug companies in the United States had a median profit margin of 17%, compared with only 3.1% for all the other industries on the Fortune 500 list. The pharmaceutical companies state that drug price increases are necessary to fund their Research & Development of new drugs. Why do Americans have to fund this R&D for the rest of the world, when the rest of the world pays significantly less for their drugs? As it is, we already play a major role in funding R&D through tax-payer funded and government research. If anything, we should be buying drugs discounted below the world market price average. The higher drug prices in the US also mean that we are paying for the marketing of these drugs to us. In some cases, Big Pharma spends twice as much on marketing, advertising, and administration as they do on R&D. This is yet another reason for us to be paying less, not more. The cost of marketing and research should not be a burden that is born by Americans, especially when those that bear this burden are the ones least able to afford it, the sick and elderly.

 

If the recent bailout of the banking industry has shown us anything, it is that compensation packages to executives tend to be outrageous. This is no less the case with Big Pharma where compensation packages reach into the tens of millions. This doesn’t make sense when senior citizens throughout America are forced to make the choice between paying the high cost of prescription drugs or buying food. As the economy faces a depression and unemployment climbs, the number of people who are in this predicament will also increase.

 

Another way to increase the quality of healthcare in America is to take back control of patient care away from insurance companies. Insurance companies do not heal or treat anyone, physicians and health practitioners do. Insurance companies have stepped into the role of determining what happens with patient care as opposed to the healthcare practitioner. Insurance companies sell a promise and then figure out every way that they can not to deliver on that promise. Patient care needs to be solely in the hands those who have been trained to address it.

 

Unless the next President and Congress make reforms that favor the interests of its citizens over that of the pharmaceutical and insurance industries, healthcare as we know it will continue on, business as usual. Some single payer plans call for lifestyle changes and patients assuming a greater degree of responsibility for their own health. These include the areas of diet, weight loss, cessation of smoking, and exercise. Although, I’m not convinced of the suitability of the single payer plans to fill our needs, they do show some merit.

 

The bottom line is that we as Americans need to take greater personal responsibility for our own health. The choice always has been and always will be ours. It is not up to others to make this right for ourselves, it is up to us.

 

Jack LaLane, an American icon, once said, “Exercise is King and Nutrition is Queen. Put them together and you have a kingdom.” Perhaps, the time has come for us to claim that kingdom.

 

 

 

 

 

 

 

 

 

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